Maybe don't add 10,000 useless objects to the game, give your character 2 hands and not an infinite inventory if you're doing this, and don't splay LOOT and other retarded shit around in areas it shouldn't be? There's no reason I should even be looking at those shelves, if your game is supposed to be realistic I shouldn't be digging through the trash to find a green herb
But I want that stuff in the game!
Then don't make me dig through it for key items, make it trash and put the key items NOT in the trash, like put the bullets inside of a cabinet or locker or whatever, or maybe on a bedroom shelf, but don't just put them in some random cardboard box they have no reason to be in in the first place.
A cluttered / busy environment I have to pick shit up in
There's no point in this, you just make the character either spam E to pick shit up they're not even looking at, or you give them a limited inventory space and punish them for not looking at 1,000 objects you placed on a shelf that are worth nothing and not gameplay-related (skyrim loves to do this)