Here's the major points he makes (sans gameplay criticism because they require video evidence):
Backstory
Luis' grandfather died when bitten by a Plaga Colmillos... decades before the Plagas were unearthed.
Luis worked for Umbrella in the division that created Nemesis... years after the development of Nemesis took place
Ramon is cured of his disease by the Plagas... years before the Plagas were unearthed
In the OG the only dominant Plaga was for Saddler, but here they add the Superior Species which is mass produced for every boss that transforms, which contradicts Damnation which says it's the first time someone managed to mass duplicate Plagas.
The file that explains the creation of the Superior Species Plaga says they just got Ashley and are going to use it on her, so it would seem that all the bosses in the game had 1-2 days to learn how to use their virus? Especially if Ashley had to drink the liquid and be in a coma for several hours for the Plaga to develop, and they all had to do the same thing.
Wesker is already commanding Tricell, so this timeline doesn't include the Rival Organization and creates continuity errors with RE1 and Umbrella Chronicles.
Krauser never met Wesker and works for Saddler unironically, so it isn't explained how he found out about a secret cult in Spain or why he is angry with Leon if Operation Javier had Krauser as the sole survivor, i.e. Leon did not participate. That Krauser was the sole survivor and became a fugitive from the government also makes it unclear how he escaped from South America to begin with.
The new Operation Javier didn't involve BOWs, which makes it impossible for the The Family in RE6 to get the Veronica Virus after Operation Javier.
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